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Extended CT Scans Uncover Hidden Stroke Clots and Drive Plans for Global Trial

After demonstrating that a brief CT extension boosts clot detection without slowing care, the team is designing a modified protocol for a prospective international trial.

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Luciano Sposato, the lead investigator and head of LHSC’s Southwestern Ontario Regional Stroke Centre.(Handout)

Overview

  • The DAYLIGHT trial enrolled 465 patients with acute stroke or transient ischemic attack at London Health Sciences Centre’s University Hospital.
  • Extending CT angiography to include the heart and aorta increased detection of cardioaortic thrombus by about 600%, revealing one previously hidden clot for every 14 patients scanned.
  • Adding a three-second scan did not delay emergency imaging or treatment and raised radiation exposure by only about 2½ mammograms’ worth.
  • Identifying a heart-origin clot enables tailored treatment decisions, with blood thinners typically prescribed to prevent recurrent strokes.
  • With results published in The Lancet Neurology, researchers are refining the CT protocol and seeking funding to launch a larger international study.