Overview

• Dengue outbreaks are occurring more frequently and spreading beyond seasonal tropical zones to become a year-round public health challenge in Argentina.
• Health authorities recommend starting the tetravalent vaccine in winter to ensure the second dose, given 90 days later, is completed before the summer peak.
• The full two-dose regimen is required because a single dose does not provide long-term protection.
• Vaccination remains crucial for individuals with prior dengue infection due to serotype-specific immunity; secondary infection carries a heightened risk of severe disease.
• TIDES clinical trials, which involved more than 20,000 participants in eight endemic countries, showed an 84% reduction in hospitalizations and a 61% drop in symptomatic dengue among vaccinated individuals.