Overview

• USA TODAY’s panel largely picks San Francisco against the spread (49ers -4.5), with one dissent opting for New Orleans.
• The matchup is set for Sept. 14 at Caesars Superdome, where the 1-0 49ers face the 0-1 Saints.
• George Kittle is on injured reserve, and Brock Purdy’s toe and shoulder are being monitored heading into the weekend.
• Live odds and lines are updating ahead of kickoff, reflecting early sentiment toward San Francisco.
• Tickets remain available via major resale platforms, including StubHub, SeatGeek and Vivid Seats.