Excess Niacin Linked to Increased Heart Disease Risk, Study Finds

New research suggests that high levels of niacin, a common B vitamin, may contribute to cardiovascular disease through inflammation and vascular damage.

• Cleveland Clinic researchers discovered a link between high levels of niacin and heart disease, identifying 4PY, a breakdown product of niacin, as a key contributor.
• Large-scale clinical studies showed that higher levels of 4PY are strongly associated with the development of heart attack, stroke, and other adverse cardiac events.
• The study, published in Nature Medicine, highlights the potential for new interventions to reduce or prevent vascular inflammation caused by 4PY.
• Despite niacin's role in lowering cholesterol, its excess may counteract benefits and contribute to higher mortality rates, challenging its use as a treatment.
• Researchers call for a reevaluation of niacin fortification in foods and caution against overuse of supplements, advocating for a balanced diet instead.

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