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Even 2–5 Cigarettes a Day Greatly Raise Heart and Death Risks, Pooled U.S. Study Finds

The PLOS Medicine analysis followed more than 320,000 adults across 22 cohorts for about two decades.

Overview

  • Compared with never-smokers, smoking 2–5 cigarettes daily was linked to about 50% higher cardiovascular disease risk and roughly 60% higher all-cause mortality.
  • Researchers recorded more than 125,000 deaths and about 54,000 cardiovascular events in the pooled follow-up.
  • Quitting reduced risk immediately and substantially in the first 10–20 years, yet former smokers may need 31–40 years for risks to approach those of never-smokers.
  • Smoking 11–15 cigarettes per day was associated with an 84% higher cardiovascular disease risk and more than double the risk of death.
  • Study authors and the American Heart Association stressed that no level of cigarette use is safe and urged clinicians to prioritize complete cessation over cutting back.