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ESC Names Vaccination the Fourth Pillar of Heart Prevention as Studies Show Post‑Infection Risk Spikes

Evidence of infection‑triggered spikes in cardiac events underscores the urgency of pre‑winter vaccination for older, high‑risk people.

Overview

  • An extensive University of California meta‑analysis of 155 high‑quality studies (1997–2024) found a roughly fivefold stroke risk and fourfold heart‑attack risk in the first four weeks after influenza infection.
  • SARS‑CoV‑2 infection was associated with a 3.1‑times higher risk of heart attack and a 2.9‑times higher risk of stroke shortly after illness, with smaller but meaningful increases also reported for HIV, hepatitis C and varicella‑zoster.
  • The European Society of Cardiology now formally classifies certain vaccinations as a standalone prevention pillar for cardiovascular disease, reflecting evidence that acute infections can trigger inflammation and coagulation that strain the vascular system.
  • National guidance stresses timely shots before winter: Austria offers free influenza and pneumococcal vaccines for people 60 and older, and Germany’s STIKO advises annual COVID‑19 boosters for those 60+ with a new influenza vaccine recommended from the 2025/26 season.
  • Uptake remains low despite benefits such as a ~34% reduction in major cardiovascular events after flu vaccination, with reported coverage around one third for flu in over‑60s, about 20% for pneumococcal protection, and 16% for last winter’s COVID booster.