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Energy-Reduced Mediterranean Diet Plus Exercise Cuts Type 2 Diabetes Risk by 31%

A peer-reviewed analysis from the PREDIMED-Plus trial reports fewer diabetes cases with structured lifestyle support layered onto the eating pattern.

Overview

  • PREDIMED-Plus randomized 4,746 adults ages 55–75 with metabolic syndrome at 23 Spanish centers and followed participants for about six years.
  • The intervention paired a Mediterranean-style diet with a planned ~600 kcal/day reduction, roughly 45 minutes of aerobic activity most days, and regular behavioral weight-loss support; controls followed an unrestricted Mediterranean diet.
  • Incident type 2 diabetes was 31% lower in the intervention group versus control, corresponding to an adjusted absolute risk reduction of about 2.4% over the study period.
  • Intervention participants lost about 3.3 kg and reduced waist circumference by 3.6 cm, compared with 0.6 kg and 0.3 cm in the control group.
  • Authors note that diabetes was a secondary outcome, adherence was self-reported, and generalizability may be limited to older adults in a Mediterranean setting; the study was funded by European and U.S. public research agencies and published August 25 in Annals of Internal Medicine.