Overview
- PREDIMED-Plus randomized 4,746 adults ages 55–75 with metabolic syndrome at 23 Spanish centers and followed participants for about six years.
- The intervention paired a Mediterranean-style diet with a planned ~600 kcal/day reduction, roughly 45 minutes of aerobic activity most days, and regular behavioral weight-loss support; controls followed an unrestricted Mediterranean diet.
- Incident type 2 diabetes was 31% lower in the intervention group versus control, corresponding to an adjusted absolute risk reduction of about 2.4% over the study period.
- Intervention participants lost about 3.3 kg and reduced waist circumference by 3.6 cm, compared with 0.6 kg and 0.3 cm in the control group.
- Authors note that diabetes was a secondary outcome, adherence was self-reported, and generalizability may be limited to older adults in a Mediterranean setting; the study was funded by European and U.S. public research agencies and published August 25 in Annals of Internal Medicine.