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17h ago

Emotional Eating Tied to Weaker Ozempic Response, External Cues Predict Better Results

A yearlong observational study of 92 people in Japan suggests simple pre-treatment behavior assessments could help tailor GLP-1 therapy.

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New research has shown GLP-1 weight loss drugs like Ozempic can’t fix everything, and one group in particular were less likely to benefit from its use.

Overview

  • Researchers followed 92 adults with type 2 diabetes in Gifu Prefecture through their first year on GLP-1 receptor agonists, publishing the findings in Frontiers in Clinical Diabetes and Healthcare.
  • Participants who reported high external eating at baseline showed the greatest long-term improvements in weight and blood glucose markers, while those prone to emotional eating benefited less.
  • Across the cohort, body weight, cholesterol, and body fat percentage declined significantly over 12 months, with skeletal muscle mass maintained and blood glucose improvements not reaching statistical significance.
  • Eating patterns shifted over time: restrained eating rose at three months then returned to baseline by 12 months, emotional eating also reverted, whereas reductions in external eating persisted throughout the year.
  • Authors stress the results are preliminary due to the study’s observational design and self-reported measures, recommending added psychological support for emotional eaters and calling for larger randomized trials.