Overview

• Organic Letters published the Emory study on June 27, 2025, detailing improvements to Cu(II)‑catalyzed C–O cross‑couplings.
• The team used a ligand to split the copper acetate dimer into active monomers and an organic peroxide to accelerate catalyst regeneration.
• Yields increased to about 80% for a model vinylic ether, with good results across at least 15 compounds new to the literature.
• The authors highlight easy reproducibility with widely available, low‑cost reagents and routine setup without oxygen gas.
• The McDonald lab intends to apply the protocol to plasmalogen‑related syntheses and other drug‑relevant targets.