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4mo ago

Eli Lilly's Oral GLP-1 Pill Demonstrates Success in Phase 3 Trials

The first nonpeptide oral GLP-1 therapy, orforglipron, matches injectable drugs in weight-loss and glucose-control efficacy, with FDA filings planned for late 2025.

An Eli Lilly and Company pharmaceutical manufacturing plant is pictured at 50 ImClone Drive in Branchburg, New Jersey, March 5, 2021.
INDIANAPOLIS, INDIANA - MARCH 17: A flag flies above the headquarters campus of Eli Lilly and Company on March 17, 2024 in Indianapolis, Indiana. Lilly, a pharmaceutical company, employs more than 12.000 people in Indianapolis and more than 42,000 worldwide. (Photo by Scott Olson/Getty Images)
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Overview

  • Orforglipron reduced A1C levels by up to 1.6% and achieved an average 7.9% weight loss in Type 2 diabetes patients over 40 weeks.
  • Over 65% of participants on the highest dose reached A1C levels at or below 6.5%, considered below the diabetic threshold.
  • The safety profile was consistent with injectable GLP-1 drugs, with mild to moderate gastrointestinal side effects reported.
  • Eli Lilly plans to file for regulatory approval for obesity treatment by the end of 2025 and for diabetes management in 2026.
  • If approved, orforglipron could simplify treatment accessibility and manufacturing, addressing global demand for diabetes and obesity therapies.