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Eli Lilly to Buy Kelonia for Up to $7 Billion to Bet on In‑Body CAR‑T

The purchase brings Lilly a one‑dose CAR‑T approach made inside the patient.

Overview

  • Lilly said Monday it will acquire Boston‑based Kelonia for $3.25 billion upfront with milestone payments that could lift the total to $7 billion, with closing expected in the second half of 2026 pending approvals.
  • Kelonia’s lead therapy, KLN‑1010, is designed to turn a patient’s T cells into anti‑BCMA CAR‑T cells with a single intravenous infusion, avoiding lab‑based cell engineering and pre‑treatment chemotherapy.
  • Early Phase 1 data presented at the ASH 2025 meeting showed rapid, deep responses in a small multiple myeloma cohort, and the FDA cleared an IND in January to expand U.S. trial sites.
  • Lilly frames the deal as a push beyond its weight‑loss blockbusters into next‑wave oncology and genetic medicines, following recent buys including Orna Therapeutics and Centessa Pharmaceuticals.
  • Lilly executives praised Kelonia’s results as “nothing short of remarkable,” while Crunchbase noted the price ranks among the largest venture‑backed biotech acquisitions in recent years after Kelonia raised about $60 million.