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Eli Lilly to Acquire Ventyx Biosciences for $1.2 Billion in Bet on Oral NLRP3 Drugs

The $14-per-share agreement brings Lilly a clinical portfolio targeting chronic inflammation, with closing targeted in the first half of 2026.

Overview

  • Lilly will buy all outstanding Ventyx shares for $14.00 each, valuing the company at about $1.2 billion.
  • The price reflects roughly a 62% premium to Ventyx’s 30-day volume-weighted average, according to the companies.
  • Ventyx adds oral NLRP3 inhibitors and other clinical programs spanning cardiometabolic, neurodegenerative and autoimmune diseases.
  • October Phase II data for VTX3232 showed a 64% drop in a heart-disease biomarker over 12 weeks versus a 3% rise on placebo.
  • The definitive deal follows reports of advanced talks that sent Ventyx shares up about 62% after hours, and it positions Lilly against rivals pursuing NLRP3 drugs such as Novo Nordisk and Roche.