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Eli Lilly Raises 2025 Outlook as Tirzepatide Sales Soar, Orforglipron Misses Marks

Q2 revenue topped $15 billion, prompting a higher full-year forecast following disappointing weight-loss results for its experimental oral obesity therapy.

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Lilly logo is seen in this illustration taken August 5, 2025. REUTERS/Dado Ruvic/Illustration
FILE PHOTO: An injection pen of Zepbound, Eli Lilly’s weight loss drug, is displayed in New York City, U.S., December 11, 2023.  REUTERS/Brendan McDermid/File Photo
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Overview

  • Eli Lilly reported Q2 revenue of $15.56 billion and adjusted EPS of $6.31, surpassing analysts’ forecasts.
  • Sales of tirzepatide drugs Mounjaro and Zepbound climbed 68% and 172% year-over-year, generating a combined $8.57 billion.
  • The company raised its fiscal 2025 revenue guidance to $60–62 billion and its adjusted EPS outlook to $21.75–23 per share.
  • Late-stage data showed its oral obesity candidate orforglipron achieved just over 12% average weight loss, falling short of expectations and triggering a more than 12% premarket share drop.
  • President Donald Trump’s proposed tariffs on imported pharmaceuticals and revived most favored nation pricing policy pose potential pressure on future profitability.