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Eli Lilly Raises 2025 Forecast on Tirzepatide Surge, Shares Dip on Orforglipron Miss

The results bolster Lilly’s full-year outlook as the company prepares to navigate forthcoming U.S. drug-pricing reforms

Lilly logo is seen in this illustration taken August 5, 2025. REUTERS/Dado Ruvic/Illustration
FILE PHOTO: An injection pen of Zepbound, Eli Lilly’s weight loss drug, is displayed in New York City, U.S., December 11, 2023.  REUTERS/Brendan McDermid/File Photo
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Eli Lilly revealed Zepbound's sales growth of 172% in its Q2 report. Credit: bella1105 via Shutterstock.com.

Overview

  • Lilly posted $15.56 billion in Q2 revenue and $6.31 adjusted EPS, topping analyst estimates on robust sales of Mounjaro and Zepbound.
  • Combined tirzepatide revenue climbed to $8.57 billion, with Mounjaro contributing $5.2 billion and Zepbound $3.4 billion, nearly doubling year-over-year sales.
  • The company lifted its 2025 guidance to $60 billion–$62 billion in sales and $21.75–$23 in adjusted EPS, up from prior ranges of $58 billion–$61 billion and $20.78–$22.28.
  • Late-stage trial data for its oral obesity pill orforglipron showed 12% weight loss at the highest dose, missing expectations and triggering a 12% share drop.
  • Lilly noted its outlook excludes President Trump’s proposed drug tariffs and flagged intensifying competition from Novo Nordisk as pricing policies evolve.