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Eli Lilly Briefly Hits $1 Trillion, First Drugmaker to Reach the Milestone

Explosive tirzepatide sales recalibrated investor expectations for Lilly’s long-term growth.

Overview

  • Lilly’s rally, up roughly 36% this year, has been fueled by booming demand for Zepbound and Mounjaro in the fast-growing GLP-1 market.
  • Third-quarter revenue rose 54% to $17.6 billion, with more than $10 billion from obesity and diabetes treatments, and the company raised full-year guidance.
  • Through the first nine months of 2025, tirzepatide products generated nearly $19 billion, overtaking Keytruda to become the world’s best-selling medicine.
  • Analysts highlight a recent White House pricing arrangement that could expand Medicare and Medicaid access in 2026, supporting higher volumes despite pricing pressure.
  • Investors are watching the oral obesity candidate orforglipron, with some expecting approval as early as 2026, as Lilly accelerates manufacturing expansion to meet demand.