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Electrospun Web Microneedle Patch Boosts Drug Delivery in Preclinical Study

Researchers report a wearable, barbed microneedle design that anchors to skin for sustained transdermal dosing.

Overview

  • Chung‑Ang University scientists created electrospun web microneedles by depositing nanoscale polymer fibers onto metal tips to mimic bee‑stinger barbs for secure skin anchoring.
  • In guinea pig tests with the Alzheimer’s/Parkinson’s drug rivastigmine, the patches released more than twice the drug and covered a five‑fold larger area than conventional approaches.
  • Pharmacokinetic data reported a roughly 2.5‑fold increase in area under the curve with prolonged blood exposure, indicating more efficient, sustained delivery versus existing methods.
  • The patches are described as soft and breathable, showed minimal irritation during wear, and any mild skin reactions resolved quickly after removal in the animal studies.
  • Findings were published July 31, 2025, in Advanced Healthcare Materials (DOI: 10.1002/adhm.202501371), with authors noting animal‑only experiments and declaring no conflicts of interest.