Overview

• Trinity College Dublin researchers applied brief pulsed electrical signals to human monocyte‑derived macrophages using a custom bioreactor and assessed responses over 24–72 hours.
• The treatment decreased inflammatory signaling and shifted the cells toward an anti‑inflammatory, regenerative phenotype associated with faster tissue repair.
• Pro‑angiogenic gene expression increased, and assays indicated greater recruitment of stem cells relevant to wound healing.
• The findings were published in Cell Reports Physical Science (DOI: 10.1016/j.xcrp.2025.102795) using donor blood sourced via the Irish Blood Transfusion Board and St James's Hospital.
• The team plans to refine stimulation regimes and explore new delivery materials, emphasizing that results are in vitro but could help optimize existing clinical wound‑healing devices.