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Edwin Arroyave Details Teddi Mellencamp’s Treatment Struggles as Family Cites Brain Lesions and Ongoing Care

Her estranged husband says treatment limits have weighed on her mental health.

Overview

  • Speaking on The Ed's podcast on January 19, Edwin Arroyave said Teddi Mellencamp "really can’t work out" and is only easing into light movement, with immunotherapy side effects taking a toll on her mental health.
  • Arroyave characterized her October 2025 scans as showing "no detectable cancer," saying doctors gave extremely low odds of that outcome while emphasizing that treatment is continuing.
  • He said Mellencamp has deepened her faith during the cancer journey, finding reassurance in scripture.
  • Arroyave noted he has taken on more day-to-day parenting duties so their children see consistent support during her illness.
  • John Mellencamp recently said doctors are monitoring 10 frontal-lobe lesions that are not cancerous at present but disrupt her thinking, and he described immunotherapy leaving her unwell for several days.