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last mo.

Edinburgh Researchers Identify 116 Blood Biomarkers for Chronic Fatigue Syndrome

Using UK Biobank data from more than 132,000 participants, the team mapped distinct immune, metabolic, liver function profiles that could transform diagnosis

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Overview

  • The study published in EMBO Molecular Medicine compared blood samples from 1,455 ME/CFS patients with those of 131,000 healthy controls to uncover potential diagnostic markers.
  • Researchers pinpointed 116 biomarkers linked to chronic inflammation, insulin resistance and liver dysfunction in individuals with ME/CFS.
  • Patients reporting post-exertional malaise showed the most pronounced biomarker differences, underscoring a unique physiological response to exertion.
  • Stable biomarker levels despite varying activity levels challenge the notion that symptoms arise from deconditioning and question the effectiveness of graded exercise therapy.
  • Investigators emphasize that findings remain preliminary and further studies are needed to confirm whether a reliable blood test can be developed.