Overview
- The randomized waitlist-controlled LIFE-L trial enrolled 72 adults receiving six-cycle chemotherapy for lymphoma, assigning 44 to the virtual program and 28 to a waitlist control.
- The intervention delivered weekly individualized remote coaching by a registered dietitian and an exercise physiologist, with 86% attendance for diet sessions and 81% for exercise.
- Eighty-one percent of eligible patients enrolled in the program, indicating strong feasibility during active treatment.
- Participants receiving the program reported lower rates of anxiety (17% vs 34%), depression (46% vs 67%), pain (22% vs 39%), fatigue (46% vs 67%), and constipation (17% vs 25%) compared with controls.
- Physical function improved in the intervention arm, including higher handgrip strength (30.2 kg vs 23.2 kg) and better gait scores, and investigators will evaluate whether the program helps maintain at least 85% of prescribed chemotherapy dose and supports longer-term outcomes.