Early Ovary Removal Linked to Reduced Brain White Matter

Study reveals significant reduction in white matter integrity in women who undergo premenopausal bilateral oophorectomy, especially before age 40.

Research analyzed MRI data from over 1,000 women, highlighting reduced white matter integrity in those with early ovary removal.
Abrupt loss of estrogen and testosterone may contribute to these changes in the brain.
The study underscores the need for further research to understand the connection between white matter changes and cognitive impairment.
80% of participants who had their ovaries removed also had a history of estrogen replacement therapy, complicating the findings.
Experts emphasize the importance of weighing potential long-term brain effects when considering premenopausal bilateral oophorectomy.