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3h ago

Early Odds, Simulations Slightly Favor Buccaneers Over 49ers in Week 6

SportsLine’s 10,000-simulation model projects Tampa Bay to cover.

Will Baker Mayfield and the Tampa Bay Buccaneers beat the San Francisco 49ers? NFL Week 6 predictions, picks, odds preview the game on Oct. 12, 2025.
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Overview

  • BetMGM posts Tampa Bay as a 3-point favorite over San Francisco with a -165 moneyline and a 47.5 total for Sunday at Raymond James Stadium.
  • CBS Sports reports the SportsLine model has the Buccaneers covering in over 50% of simulations and projects the Over to cash in a majority of runs.
  • ESPN’s matchup predictor gives the Buccaneers a 51.1% chance to win, with the 49ers at 48.5%.
  • Aggregated picks from multiple outlets lean toward Tampa Bay, though at least one model (Sports Betting Dime) favors San Francisco by a narrow margin.
  • CBS highlights additional model-backed Week 6 bets, including a top play on the Cowboys to cover against the Panthers, alongside promotional parlay offerings and performance claims.