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Eagles Open Season Sunday With New Play-Caller, Key Injuries and Favorable Odds

The opener will test whether roster turnover and Sean Mannion’s Shanahan‑style offense can yield quick gains for Jalen Hurts or put additional pressure on coach Nick Sirianni.

Overview

  • The Philadelphia Eagles will host the Washington Commanders at Lincoln Financial Field on Sunday at 4:25 p.m. in the 2026 regular-season opener.
  • Philadelphia replaced offensive coordinator Kevin Patullo with Sean Mannion, who is expected to run a Shanahan/McVay-influenced scheme as he makes his NFL play-calling debut.
  • Recent availability updates have knocked edge rusher Jonathan Greenard out of Week 1 and A.J. Brown, traded to New England this offseason, is dealing with a high-ankle sprain that could cost him roughly a month.
  • National and local pundits plus betting markets favor the Eagles, citing Philadelphia’s rebuilt offensive line and a strong defensive front as advantages despite questions about the new offense.
  • The game will shape early narratives because pressure is high after a disappointing title defense, and Week 1 performance could quickly influence perceptions of Jalen Hurts, Nick Sirianni, and the team’s direction.