Overview
- The Eagles announced Saquon Barkley, Jalyx Hunt, Michael Carter II, A.J. Epenesa, Hollywood Brown and Joe Milton III as inactive for Week 6.
- Tanner McKee will start at quarterback with rookie Cole Payton as the primary backup and Joe Milton III listed as the emergency third QB after a late signing.
- Philadelphia enters the game without its top three running backs because Barkley is out and Tank Bigsby and Will Shipley remain on injured reserve, leaving Dameon Pierce, Carson Steele and Jaydon Blue to carry the workload.
- Edge depth is reduced by Hunt and Epenesa being inactive, which opens playing time for Jonathan Greenard, Nolan Smith, Arnold Ebiketie and Keyshawn James-Newby in James-Newby's NFL regular-season debut.
- Drew Kendall was ruled active after being questionable but is limited and may be available only in an emergency, and the Panthers listed five players as questionable which adds uncertainty to matchups on both lines.