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Drifted H3N2 ‘Subclade K’ Spreads to U.S. as Early Flu Wave Builds

Preliminary data indicate reduced vaccine match with continued protection against severe illness.

Overview

  • U.S. surveillance shows overall flu activity remains relatively low but is rising among children and young adults, and the H3N2 subclade K has now been detected nationally.
  • Subclade K accounts for about 90% of recent influenza cases in countries such as the United Kingdom and Japan and is becoming dominant across North America and Europe.
  • Scientists report antigenic drift in the variant’s haemagglutinin that differentiates it from the vaccine strain and may lower vaccine effectiveness this season.
  • This season’s vaccine could not be updated in time for the drifted strain, yet experts and the CDC still recommend vaccination for protection, particularly for high‑risk groups.
  • Health systems in parts of Asia, including multiple provinces in China, report high flu activity with crowded hospitals, especially for pediatric patients.