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DRC Experiences Largest Bundibugyo Ebola Outbreak as Vaccine Trial Begins

The Tumaini trial has started to test whether existing and candidate vaccines protect against Bundibugyo which could alter how the region contains the virus.

Overview

  • By Oct. 23 the Democratic Republic of Congo had recorded roughly 9,700 cases and more than 4,600 deaths in the Bundibugyo outbreak making it the country’s largest Ebola epidemic on record.
  • Cross‑border importations have produced small, traceable clusters with Kenya reporting nine cases and two deaths tied to one cluster and Nigeria confirming a single linked case under expanded contact tracing.
  • On Oct. 23 responders launched the Tumaini ring‑vaccination trial in Bunia, starting with Ervebo vaccinations and planning to add Bundibugyo‑specific candidates from Oxford and Moderna to measure safety and efficacy.
  • Response operations are being undermined by violence, community mistrust, and access problems that have included attacks that killed a nurse and wounded a health worker and that slow contact tracing and care.
  • Regional governments have tightened screening and quarantine rules, including Uganda’s Oct. 25 order for a 21‑day quarantine for returnees from DRC, and officials say trial results and security will shape whether the epidemic can be contained.