Overview
- Published November 24, 2025 in the Journal of Neuroscience, the study is titled “DMT‑Induced Shifts in Criticality Correlate with Self‑Dissolution” (DOI: 10.1523/JNEUROSCI.0344-25.2025).
- Intravenous DMT produces a pronounced suppression of alpha activity and shifts oscillatory dynamics toward subcritical regimes, with higher entropy and lower complexity in alpha and adjacent bands.
- The magnitude of shifts in alpha and theta criticality correlates with participants’ ratings of self‑dissolution during the experience.
- Researchers present DMT as a rapid experimental probe for investigating how the brain constructs self‑awareness and other altered states of consciousness.
- The paper notes a conflict of interest disclosure that one author holds shares in Aspect Neuroprofiles BV, and the findings are framed as basic science rather than clinical guidance.