Overview
- Alexei Popyrin defeated Novak Djokovic in a four-set match, marking Djokovic's earliest US Open exit since 2006.
- Carlos Alcaraz also faced an early exit, leaving the tournament without its top two seeds in the men's draw.
- Jannik Sinner, Daniil Medvedev, and Frances Tiafoe are now among the favorites to win the title.
- Coco Gauff continues to advance in the women's draw, demonstrating resilience in her matches.
- The absence of Djokovic, Federer, and Nadal marks the first time since 2002 that none of the Big Three have won a major title in a season.