Overview
- Four matchups anchor the weekend: Bills at Broncos (-1.5), 49ers at Seahawks (+7), Texans at Patriots (-3) and Rams at Bears (-3.5).
- Seattle hosts San Francisco with a top-ranked defense by EPA, a run-heavy approach and a total near 45 after a recent 13-3 meeting between these rivals.
- Injury headlines include 49ers TE George Kittle out for the postseason, Seahawks QB Sam Darnold questionable with an oblique but expected to suit up, SF LB Fred Warner ruled out, Texans WR Nico Collins out, Bills S Jordan Poyer out with multiple Buffalo starters banged up, and Bears WR Rome Odunze listed as questionable but expecting to play.
- Analytics-focused prop cards highlight Christian McCaffrey Over 50.5 receiving yards for San Francisco, Seattle RB Zach Charbonnet Over mid-40s rushing yards, and Chicago rookie Luther Burden III Over 37.5 receiving yards.
- SportsLine says its locked six-leg longshot parlay includes an alternate Over 48.5 in 49ers–Seahawks, projecting 50 total points, with the site touting a potential $1 million payout on a $10 bet.