Overview

• Researchers identified USP50 as a key regulator in choosing enzymes for DNA replication, ensuring genetic stability.
• The absence of USP50 leads to uncoordinated enzyme use, resulting in replication errors and genetic instability.
• USP50's regulation of nucleases and helicases is vital for ongoing replication, fork restart, and telomere maintenance.
• The study offers insights into how genetic changes may contribute to early-onset aging and cancer.
• Understanding USP50's role may pave the way for new therapeutic strategies to protect DNA integrity.