Overview

• Flaviviridae viruses cause severe diseases like dengue, Zika, and Japanese encephalitis, affecting millions globally.
• Current treatments are limited to supportive care, highlighting the need for effective antiviral drugs and vaccines.
• Recent study identifies IPO7 protein as essential for nuclear translocation of flavivirus core proteins, crucial for virus replication.
• Blocking IPO7 could significantly reduce viral particle production, offering a new therapeutic target.
• Researchers used CRISPR/Cas9 to demonstrate that cells lacking IPO7 produced fewer viral particles despite similar viral loads.