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Digital Patient Outreach Raises Lung CT Screening to 24.5% in JAMA Trial

The real-world study evaluated a patient-directed decision aid delivered outside clinic visits.

Overview

  • In a randomized multicenter trial of 1,333 screening-eligible adults at two U.S. health systems, mPATH-Lung outperformed enhanced usual care at 16 weeks.
  • Screening completion reached 24.5% with the digital program versus 17.0% with control, with similar results when limited to low-dose CT scans.
  • The intervention led to more screening orders (29.6% vs 18.8%), while order-to-scan completion was identical at 76% in both groups.
  • False-positive CT results were more frequent with the digital approach (12.7% vs 8.4%), and no screening-related complications were reported.
  • Researchers noted improvements across demographic groups, as an accompanying editorial highlighted limited reach with only 12% completing eligibility assessment and called for broader strategies.