Overview

• The GeroScience study found a 24-hour in vitro treatment with nicotinamide and EGCG reinstates GTP to youthful levels in neurons from aged Alzheimer’s model mice.
• Revived GTP levels activate key GTPases Rab7 and Arl8b, restoring autophagy to clear amyloid-beta aggregates and lower oxidative stress.
• A GEVAL fluorescent sensor mapped GTP dynamics and pinpointed mitochondrial energy decline as a driver of impaired cellular cleanup in aging neurons.
• The nonpharmaceutical approach suggests a potential low-risk strategy to combat age-related cognitive decline and Alzheimer’s using readily available dietary supplements.
• Researchers are now refining delivery methods and preparing live animal studies to validate in vivo efficacy and overcome oral inactivation challenges.