Overview
- AlphaGenome predicts how DNA variants influence biology across coding and non‑coding regions, analyzing sequences up to about one million bases with single‑letter resolution.
- In Nature’s comparative evaluations, the system topped leading approaches in 25 of 26 benchmark tests.
- The tool has been available for non‑commercial research for roughly six months and is already used by more than 3,000 researchers in 160 countries.
- Training drew on human and mouse genomes plus large public functional genomics resources such as FANTOM5, ENCODE, 4D Nucleome and GTEx.
- Creators and independent scientists cite strong potential for rare‑disease diagnosis and cancer research while stressing the need for broader, higher‑quality datasets and improved cell‑ and tissue‑specific, personalized predictions.