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6d ago

Danish Real-World Study Finds PSMA PET/CT Before Salvage Radiotherapy Boosts Prostate Cancer Survival

Analysis of nationwide registry data from 2015 to 2023 shows that prior PSMA PET/CT raises long-term survival, prompting calls for earlier use of molecular imaging in prostate cancer care.

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Overview

  • The study evaluated 844 men with biochemical recurrence after radical prostatectomy, comparing 308 who underwent PSMA PET/CT before salvage radiotherapy to 536 who did not.
  • Patients imaged with PSMA PET/CT achieved one-, two-, and five-year overall survival rates of 100%, 99.5%, and 98.1%, versus 99%, 97.8%, and 93.8% in the non-PSMA PET/CT group.
  • Three-year biochemical recurrence-free survival reached 74.9% among PSMA PET/CT patients compared to 69.4% for those without the scan.
  • Researchers leveraged Denmark’s staggered regional adoption of PSMA PET/CT from 2015 to 2023 as a natural experiment using routine clinical registries.
  • Authors recommend earlier integration of PSMA PET/CT into salvage radiotherapy planning to improve patient selection and guide national imaging-policy decisions.