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Daily Vitamin D3 Supplementation Slows Cellular Aging by Preserving Telomeres

The VITAL trial followed more than 1,000 U.S. adults for four years, finding that a daily 2,000 IU dose preserved telomere length by an amount equivalent to nearly three years of aging.

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Overview

  • The VITAL trial was a four-year, randomized, double-blind, placebo-controlled study of over 1,000 U.S. adults aged 50 and older.
  • Scientists tracked white blood cell telomere length at the start of the study, at two years, and after four years to monitor cellular aging.
  • Daily 2,000 IU vitamin D3 supplementation significantly reduced telomere erosion, while omega-3 fatty acids had no observable effect on chromosome end caps.
  • Study co-author Dr. JoAnn Manson highlighted that those with higher inflammation or increased risk of chronic diseases may gain particular benefit from vitamin D3.
  • Officials advise most adults to take 10 micrograms of vitamin D per day and warn against exceeding 100 micrograms to prevent hypercalcemia, with dietary sources including oily fish and fortified foods.