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Daily Pantoprazole Cuts ICU Bleeding and Hospital Costs, JAMA Study Finds

Researchers analyzed 4,821 patients across 68 ICUs to quantify savings per ventilated patient.

Overview

  • The study estimated a mean total cost of $60,466 with pantoprazole versus $65,423 without it, a savings of $4,957 per patient.
  • Patients given the drug had shorter stays, averaging 12.4 vs 13.3 days in the ICU and 14.8 vs 16.5 days in the hospital.
  • Probabilistic modeling showed pantoprazole was more effective and less costly in 99% of simulations.
  • Applying U.S. unit costs in sensitivity analysis increased estimated savings to $10,591 per patient.
  • At 50 cents to $2 per dose, the low price and savings that persisted after excluding the highest-cost decile support routine ICU use.