Overview
- Cruz Azul defeated the Seattle Sounders 4-1 in Mexico City, scoring three goals in the final 19 minutes to advance with a 4-1 aggregate win.
- Carlos Rodriguez, Angel Sepulveda, Luka Romero, and Jorge Sanchez scored for Cruz Azul, who will face either Chivas de Guadalajara or Club America in the quarterfinals.
- Despite a 2-1 loss to the Columbus Crew in the second leg, LAFC advanced with a 4-2 aggregate victory, capped by Denis Bouanga's stoppage-time goal.
- The Crew, led by former LAFC player Diego Rossi, mounted a strong first-half performance but ultimately fell short of overturning the aggregate deficit.
- Tigres UANL defeated FC Cincinnati 3-1 in the second leg, advancing with a 4-2 aggregate score thanks to three quick goals in the second half, and will face either the LA Galaxy or Herediano in the next round.