Overview
- The CDC-funded INSPIRE study followed more than 1,400 individuals with COVID-like symptoms, roughly 75% of whom tested positive for SARS-CoV-2 between December 2020 and August 2022.
- Most participants recovered optimal physical health within three months, whereas mental well-being improvements were more gradual and peaked between six and nine months.
- Approximately one in five study subjects continued to experience poor overall health-related quality of life up to 12 months after their illness, reflecting persistent long COVID impacts.
- COVID-positive participants were statistically more likely than COVID-negative peers to achieve optimal health-related quality of life, a disparity researchers suggest may stem from undiagnosed conditions or false-negative tests.
- Study authors recommend expanding mental health services and developing targeted care models to address enduring psychological and cognitive challenges post-infection.