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COVID-19 Infection Tied to Elevated Asthma and Sinusitis Risks; Vaccination Shows Protective Effect

Researchers analyzed over six million U.S. electronic health records to compare respiratory inflammation outcomes after COVID-19 infection versus vaccination.

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Overview

  • Prior SARS-CoV-2 infection was associated with a 66% higher risk of asthma, a 74% increase in chronic sinusitis and a 27% rise in hay fever compared with uninfected controls.
  • Vaccination against COVID-19 corresponded to a 32% lower asthma risk and modest reductions in chronic sinusitis and hay fever relative to unvaccinated individuals.
  • Direct comparison revealed people with prior infection faced more than double the risk of asthma or chronic sinusitis and about 40% higher hay fever risk than vaccinated counterparts.
  • The retrospective cohort study drew on TriNetX data covering 973,794 infected patients, 691,270 vaccinated individuals and 4,388,409 healthy controls.
  • Authors emphasized that the observational design precludes causal conclusions and flagged potential biases from undiagnosed infections, self-testing and author affiliations with TriNetX.