Overview
- Notable ties include Ourense–Girona, Portugalete–Alavés, Reus–Real Sociedad, Sant Andreu–Celta, Atlético Baleares–Espanyol and Cartagena–Valencia.
- The RFEF split teams into north and south groups to reduce travel and encourage local attendance.
- Matches are scheduled for 2–4 December with the lower-category side at home in single-leg fixtures.
- VAR will not be used in this round, and some host venues still require approvals, such as Sant Andreu’s Narcís Sala lighting.
- Barcelona, Real Madrid, Atlético de Madrid and Athletic Club will enter at the round of 32 due to Supercopa participation.