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Confined Dewetting Technique Yields Uniform Metal Nanoparticles for Ultra-Sensitive Sensing

Researchers are advancing the approach toward scalable production of oxidation-resistant nanoparticles capable of picomolar biomarker detection.

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Overview

  • The method sandwiches a super-thin metal film between a substrate and a PDMS layer during heating to drive uniform nanoparticle formation.
  • Nanoparticles exhibit tightly packed densities with nanometer-scale gaps and remain pure and stable under ambient conditions.
  • Samples show strong localized surface plasmon resonance and surface-enhanced Raman scattering signals for advanced optical sensing.
  • In trials with a probe molecule, the particles detected concentrations as low as one picomolar, surpassing conventional sensor sensitivity.
  • Backed by DST’s NM-ICPS and SERB funding, the team plans to scale up the versatile process across metals and substrates for biomedical and environmental applications.