Overview
- Two-legged First Round ties run from February 3 to 26, 2026, with kickoff times listed in Mexico City time and venues specified across the region.
- Mexican First Round matchups are Pumas UNAM vs San Diego FC, Tigres UANL vs Forge FC, Club América vs Olimpia, CF Monterrey vs Xelajú, and Cruz Azul vs Vancouver FC.
- Toluca skips the First Round as the best-positioned 2024–25 champion and will meet the Pumas–San Diego winner in the Round of 16 on March 11 and March 18.
- Quarterfinals are set for April 7–9 and April 14–16, semifinals for April 28–30 and May 5–7, and the final for Saturday, May 30, 2026.
- Under an agreement to support World Cup preparation, Mexican clubs reaching the semifinals cannot use players called to the national team.