Overview

• Scientists used Concanavalin A to enrich low-abundance mannosylated blood proteins and identified over 240 ligands for the mannose receptor Mrc1 in mice.
• In Mrc1-deficient animals, 244 blood glycoproteins doubled or more in concentration, demonstrating Mrc1’s central role in clearing these molecules.
• Among the newly identified ligands are renin and angiotensin-converting enzymes, linking Mrc1 activity directly to blood pressure regulation.
• Loss of Mrc1 accelerated mortality in septic mice, revealing the receptor’s protective function during systemic infection.
• Comparison with human sepsis samples showed that half of the dysregulated pathways overlap with those driven by Mrc1 dysfunction