Overview

• Researchers from KTH and Stanford published a Cell study using advanced imaging and antibody-based spatial proteomics across three human cell types.
• They analyzed more than 128,000 individual cilia to chart protein locations within the organelle’s distinct regions.
• The atlas lists 715 ciliary proteins, including 91 not previously linked to cilia, expanding targets for basic and translational research.
• Findings show intrinsic heterogeneity, with primary cilia tailoring their protein composition to the needs of different cell types.
• Data are publicly available via the Human Protein Atlas, and a candidate CREB3 variant was flagged in one patient as a potential ciliopathy link pending further validation.