Overview
- At 8-4 apiece, the winner will move into sole possession of the AFC South lead with four games remaining.
- Periods of heavy rain and thunderstorms with near-12 mph wind gusts are projected around kickoff, according to ESPN's Adam Schefter.
- Oddsmakers list Indianapolis as a slight road favorite at roughly 1.5 points.
- Colts QB Daniel Jones is playing through a lower-leg, reportedly fractured fibula injury that has limited his mobility, with CB Sauce Gardner expected out and DE Tyquan Lewis ruled out.
- Jacksonville has won three straight and four of five, boasts a top-ranked run defense, and has beaten Indianapolis in 10 consecutive home meetings.