Overview
- The Colts issued their final Week 1 injury report before the opener and officially ruled linebacker Austin Ajiake out with a hamstring, prompting the elevation of rookie cornerback Kenneth Harris.
- Wide receiver Alec Pierce practiced limited through the week for a heel issue but was listed available with coaches signaling he may have a managed snap count.
- Quarterback Daniel Jones cleared practice and has no game designation, marking his first regular-season appearance since his 2025 Achilles surgery and making him a cautious fantasy start.
- Running back Jonathan Taylor is not on the report and is treated as the team's lead back, while safety AJ Haulcy finished with back-to-back full practices and is set to start.
- Veterans DeForest Buckner and Grover Stewart were given 'rest' designations after skipping practices but remain available, a move that preserves depth without changing game plans.