Overview

• Indianapolis has piled up 163 points in five games as Daniel Jones delivers career-best efficiency and Jonathan Taylor leads the NFL with 480 rushing yards.
• Kyler Murray is listed as questionable with a foot injury after a limited Friday practice, with Jacoby Brissett in line to start if he is unavailable.
• Betting markets lean toward Indianapolis with a spread around Colts -7 and a moneyline near -310, and multiple previews forecast a home win.
• Arizona’s defense ranks No. 1 in EPA through three quarters but 27th in the fourth, a late-game drop-off highlighted by last week’s 22-21 loss after leading 21-3.
• Key availability notes include Kenny Moore II ruled out (Achilles), Alec Pierce cleared to return and Grover Stewart expected to play for the Colts, while Arizona ruled out Darius Robinson and fined coach Jonathan Gannon $100,000 for striking Emari Demercado.