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Colts at Chargers on CBS: Tight Line and Split Picks for Week 7

Betting markets and expert projections diverge as Los Angeles’ injury issues collide with Indianapolis’ surging offense.

Will Ladd McConkey and the Los Angeles Chargers beat the Indianapolis Colts on Sunday? NFL Week 7 predictions, picks, odds preview the game on Oct. 19, 2025.
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Overview

  • Kickoff is Sunday, Oct. 19 at 4:05 p.m. ET at SoFi Stadium on CBS, with Ian Eagle, JJ Watt and Evan Washburn on the call.
  • The Colts enter 5-1 and the Chargers 4-2 in a consequential AFC matchup at a venue where Indianapolis fell to the Rams in Week 4.
  • Sportsbooks list Los Angeles as a slight favorite (about -1 to -1.5) with a total near 48.5 points, reflecting a tightly priced game.
  • USA TODAY’s picks panel is split on the spread, mirroring wider analytical disagreement on which side has the edge.
  • The Chargers’ defense has been hit by injuries, including Khalil Mack’s absence, while the Colts’ attack—powered by Daniel Jones, Jonathan Taylor and standout rookie TE Tyler Warren—has produced consistently high scores.