Overview
- Recent reporting confirms Pierce had a second platelet-rich plasma (PRP) injection after the late-March 'clean-up' surgery on his left ankle, though the team did not disclose exactly when the shot was given.
- Colts and league sources characterized the injection as a healing measure for lingering soreness rather than a sign of a rehab setback.
- Pierce remains on the Colts' Physically Unable to Perform list and coaches have not provided a concrete timetable for his return to practice or games.
- The PRP shot follows an earlier post-2025-season PRP attempt to avoid surgery and a March procedure that carried an estimated four-to-six-month recovery window.
- Pierce's availability matters for roster planning because of his four-year, $114 million contract and the offseason trade of Michael Pittman Jr., which increases pressure on the remaining receiver group and could affect early-season depth and game planning.